ARTICLE
Brain biopsy in the diagnosis of Creutzfeldt-Jakob disease with a history of prodromal psychiatric symptoms and catatonic behavior
 
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1
Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
 
2
Department of Neurology, Jagiellonian University Medical College, Kraków, Poland
 
3
Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University Medical College, Kraków, Poland
 
4
Department of Neuropathology, Chair of Pathomorphology, Jagiellonian University Medical College, Kraków, Poland
 
 
Submission date: 2016-03-21
 
 
Final revision date: 2016-05-29
 
 
Acceptance date: 2016-06-02
 
 
Publication date: 2016-10-05
 
 
Corresponding author
Adrian Andrzej Chrobak   

Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland, Sienkiewicza street 8/12, 30-033 Cracow, Poland
 
 
Arch Psych Psych 2016;18(2):48–53
 
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ABSTRACT
Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disorder belonging to the group of transmissible spongiform encephalopathies. Transition of physiological, soluble, neuroprotective prion protein PrPc into its insoluble, misfolded isoform PrPSc remains the central pathogenic event in this disorder. Their progressive accumulation within the brain tissue results in spongiform degeneration and plethora of clinical symptoms. Typically, CJD manifests as progressive dementia with myoclonus, visual or cerebellar dysfunction, pyramidal/extrapyramidal signs or akinetic mutism. However, growing number of studies indicate that CJD may present with prodromal psychiatric manifestations including anhedonia, anxiety, irritability, depression, insomnia, psychosis and catatonic behaviour. We present case of biopsy proven CJD with a history of prodromal psychiatric symptoms and catatonic behaviour.
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ISSN:1509-2046