ARTICLE
Detoxification of high-dose zolpidem using phenobarbital and gabapentin: two case reports
1
Neurosurgery and Neurofunctional research centre, ShahidBeheshti University of Medical Sciences, Tehran, Iran
2
Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3
Department of Clinical Pharmacy, School of Pharmacy, ShahidBeheshti University of Medical Sciences, Tehran, Iran
Submission date: 2016-09-26
Final revision date: 2016-10-22
Acceptance date: 2016-10-24
Publication date: 2016-12-05
Corresponding author
Alireza Shamsi
Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Velenjak, 9185874167 Tehran, Iran
Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Velenjak, 9185874167 Tehran, Iran
Arch Psych Psych 2016;18(4):16–19
KEYWORDS
TOPICS
ABSTRACT
Zolpidem is a hypnotic drug from imidazopyridine family that is chemically distinct from classic benzodiazepines (BDZ). Contrary to classic BDZ, zolpidem acts selectively on α 1 subunit-containing GABA-A benzodiazepine (BZ1) receptors. There are a considerable number of zolpidem dependence case reports in the recent psychiatric literature. Regarding the similarities of zolpidem and BDZ in pharmacodynamic and addictive characteristics, writers posits that recommended detoxification protocols for short half-life BDZ, may also be useful in high doses zolpidem withdrawal symptoms management. Safety and effectiveness of phenobarbital for inpatient BDZ detoxification has been established in previous researches and it may be useful for zolpidem detoxification.
Project no. RCN/SN/0189/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 200 000
Amount funded by the MEiN: PLN 80 000
Aims of the project: Publication in Open Access mode on the Internet of 8 consecutive issues of the journal Archives of Psychiatry and Psychotherapy (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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