Zolpidem is a hypnotic drug from imidazopyridine family that is chemically distinct from classic benzodiazepines (BDZ). Contrary to classic BDZ, zolpidem acts selectively on α 1 subunit-containing GABA-A benzodiazepine (BZ1) receptors. There are a considerable number of zolpidem dependence case reports in the recent psychiatric literature. Regarding the similarities of zolpidem and BDZ in pharmacodynamic and addictive characteristics, writers posits that recommended detoxification protocols for short half-life BDZ, may also be useful in high doses zolpidem withdrawal symptoms management. Safety and effectiveness of phenobarbital for inpatient BDZ detoxification has been established in previous researches and it may be useful for zolpidem detoxification.