In vivo stress model points (-)-α-Bisabolol as an alternative to relieve effects on neuropsychiatric disorders
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Federal University of Ceara
Ceara Cancer Institute
Submission date: 2023-05-11
Final revision date: 2023-11-18
Acceptance date: 2023-11-22
Publication date: 2024-06-25
Corresponding author
Francisca Cléa Florenço de Sousa   

Federal University of Ceara
Arch Psych Psych 2024;26(2):45-57
Aim of the study:
The present study aimed to investigate the antidepressant and anxiolytic effect of (-)-αbisabolol (BIS) and its possible mechanisms of action related to alterations on products of oxidative stress, using the model of depression induced by Chronic Unpredictable Mild Stress

Subject or material and methods:
The male C57BL/6 mice were exposed to CUMS for 28 days, and the depressive and anxious-like behaviors was observed in the animals at the end of the protocol.

The depressive and anxious behavior was successfully attenuated after BIS administration, evidenced in forced swimming tests and preference for sucrose solution results, with exciting results when compared to Fluoxetine, the reference drug for depression.

The antioxidant profile as mechanism indicated a significant reduction of thiobarbituric acid reactive substances (TBARS) levels in hippocampus area.

In brief, the study revealed that BIS relieve depressive and anxiety-like state through mitigating oxidative stress.

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