Investigating the mediational role of Intolerance of Uncertainty and its components in reducing symptoms of emotional disorders: A double-blind randomized clinical trial
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Education & Treatment Center of Beheshti Hospital, Zanjan University of Medical Sciences
Education & Treatment Center Of Valiasr, Zanjan University of Medical Sciences
Zanjan University of Medical Sciences
Submission date: 2019-05-07
Final revision date: 2019-08-27
Acceptance date: 2019-09-18
Online publication date: 2020-06-25
Publication date: 2020-06-25
Corresponding author
Omid Saed   

Zanjan University of Medical Sciences
Arch Psych Psych 2020;22(2):72-80
Aim of the study:
Intolerance of uncertainty (IU) is a transdiagnostic structure that plays an important role in developing and maintaining symptoms of emotional disorders. The current study was aimed to investigate the mediational role of IU and its components in reducing symptoms of emotional disorders.

Subject or material and methods:
This was a double-blind randomized clinical trial. Based on the Beck anxiety inventory and Beck depression inventory 26 individuals were selected. They were randomly assigned into two groups of control and treatment (n=13) using random number generator 3.1.v software. The treatment group received 20 one-hour sessions of Unified Protocol (UP) for the transdiagnostic treatment of emotional disorders. Beck depression inventory, the Beck anxiety inventory, and Intolerance of uncertainty scale were performed in pre, post and three months follow-up. Data were analyzed by SPSS-20 software.

After controlling the effect of IU, the results of one-way analysis of covariance (ANCOVA) showed a significant reduction in the difference between the two groups (P<0.05); which means that IU can be considered as a mediator of reductions in anxiety and depression in UP. The results of the stepwise regression analysis indicated that prospective IU and inhibitory IU could explain 61.4% and 8.2% of variances in anxiety scores, respectively. In predicting changes in depression score, only inhibitory IU could explain depression variance (43.3%).

The best predictor of the changes in the anxiety and depression are, respectively, prospective IU and inhibitory IU.

This study shows that UP may exert its effect by improving different components of IU.

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