Piecewise polynomial regression model for interpretation of risperidone depot concentration versus time data
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Psychiatric Clinic
Submission date: 2015-12-16
Acceptance date: 2016-02-08
Publication date: 2016-05-01
Corresponding author
Horst Josef Koch   

Psychiatric Clinic, Gartensstraße 6, 08280 Aue, Germany
Arch Psych Psych 2016;18(1):5-7
Risperdal ConstaTM (risperidone) was the first long-acting depot formulation of an atypical antipsychotic belonging nowadays to standard treatments for schiz-ophrenic patients. The microsphere technology of this depot formulation re-sults in a complex pharmacokinetics with a delay (lag time) of relevant drug levels for 3 to 4 weeks, which therefore initially requires additional oral doses. The piecewise polynomial regression approach based on sign functions was used to define the complex concentration versus time curve after a single in-tramuscular injection. A 3-phase linear model with logarithmic transformation of concentration data was suited to fit the concentration time data and gave valuable data on both half-lives and phase borders (deflection points).
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