Aim: This case report addresses some clinical challenges occurring throughout the therapeutic process of specialized management treatment of Anorexia Nervosa with comorbid Borderline Personality Disorder. Materials and method: Clinical examinations and measures – Structured Clinical Interview for DSM-IV (SCID-II), Eating Attitudes Test (EAT-26), Yale-Brown Obsessive Compulsive Scale modified for Body Dysmorphic Disorder (BDD-YBOCS), Beck Depression Inventory-II (BDI-II), Toronto Alexithymia Scale (TAS-20), and State-Trait Anxiety Inventory (STAI) have been employed to identify the nature and severity of patient’s psychopathology and its potential change throughout the therapeutic process. Results: Despite some improvement in the symptoms of the eating disorder following the treatment, some other measures of psychopathology (e.g., depression) remained at similar level. Conclusions: Only partial improvement in the profile of F.C.’s psychopathology was observed. Discussion: Management of AN with comorbid BPD requires a comprehensive care package including integrative psychotherapy, nutritional interventions and pharmacotherapy at an inpatient setting as well as follow-up care thereafter.