Association study of the Brain-Derived Neurotrophic Factor (BDNF) gene C-270T polymorphism with bipolar affective disorder
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Arch Psych Psych 2006;8(1):31–39
Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of bipolar disorder. In this paper, the C-270T polymorphism of the BDNF gene has been studied in patients with bipolar disorder (n=380) and in the control group (n-380). Consensus diagnosis was made for each patient, according to DSM-IV, using SCID. Genotypes were determined by PCR-RFLP analysis. No association was found between the polymorphism studied and bipolar disorder. Results were also not significant when analyzed by gender and age at onset. Analysis in subgroups according to disease subtype (I and II) also did not reveal any significant differences between bipolar I and II patients and the control group.