Aim. The authors explored the metabolic profile of patients with cognitive dysfunctions by means of levels of lipoproteins, glycaemia and hypertension. Research Design and Methods. In a prospective, randomised manner, we studied 100 persons - 44 without cognitive dysfunctions, 56 with cognitive dysfunction. Patients were grouped according to ICD-10 criteria of dementia and STMS cut-off levels. Results. We found independent risk factors of dementia, which are HDL cholesterol (p=0.03), hyperglycaemia(p=0.008), dyslipidemia atherogenic (p=0.0017), metabolic syndrome (p=0.03) and age (p=0.001). We confirmed also correlations of glucose levels with CT changes, and age, fasting glucose, HDL levels with STMS results. Conclusions. Cardiometabolic syndrome seems to be a risk factor of dementia.