Haplotype analysis of DRD2 and ANKK1 gene polymorphisms in alcohol dependence
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Arch Psych Psych 2012;14(2):5–10
Aim. The aim of the study was to prove the hypothesis that the DRD2 and ANKK1 gene haplotypes, containing the polymorphic variant associated with reduced DRD2 availability predisposes to a severe form of alcohol dependence. Methods. The authors studied haplotypes of 3 SNPs (rs 1799732, rs 6276, rs 1800497) and one DRD2 intron 2 STRP (dinucleotide microsatellite polymorphism) in 85 male alcoholics. Results. Data have shown that the haplotypes are more common in the withdrawal without complications subgroup and more common in the withdrawal with complications (delirium or/and seizures) subgroup. Conclusion. The results do not confirm the initial hypothesis but suggest a discriminative role of STRP in the severity of alcohol dependence.