Depressive symptoms and preclinical Alzheimer's disease
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Arch Psych Psych 2005;7(3):13–17
The study investigated the relationship between depressive symptoms and preclinical phase of Alzheimer's disease (AD). 324 non-demented nursing home residents were included. Subjects who entered the study underwent annual follow-up evaluation for up to 6 years. We compared the result of MADRS (Montgomery and Asberg Depression Rating Scale) and GDS (Geriatric Depression Scale) scales at baseline between the demented and non-demented subjects at six years follow-up. The differences were observed in the results of the both depression scales - MADRS and GDS. Comparison between the frequencies of the occurrence of symptoms making up the MADRS reveals differences which apply to some items in terms of frequency and intensity.