Lipedema is a chronic and under-diagnosed condition affecting mainly women, characterized by a disproportionate accumulation of adipose tissue in the abdomen, hips and lower limbs, often accompanied by neuropathic pain. The complexity of the condition extends beyond the physical symptoms to include significant psychosocial impact, exacerbated by frequent misdiagnosis and lack of awareness among patients and healthcare professionals. People with lipedema often experience psychological distress and social stigma, increasing the risk of anxiety, depression and eating disorders. Effective treatment requires a multidisciplinary approach, integrating physical therapy with robust psychological and sometimes psychiatric support systems. Increasing clinicians' awareness and understanding of lipedema is essential to improve diagnosis, treatment and prevention of associated psychiatric disorders. This article discusses the epidemiology, pathogenesis and comprehensive management strategies for lipedema with the aim of improving patient outcomes and quality of life.